The life sciences industry in the United States is at a crossroads. On the one hand, the industry faces boundless opportunities for improving health care outcomes and services. On the other hand, commercialization of scientific advancements has proven to be challenging, creating significant underutilization of societal resources. Entrepreneurship in established corporations and newly spawned entities offers a critical piece of the puzzle to address this problem. This workshop brings together a diverse set of innovators and strategic thinkers in entrepreneurial, investment, and governmental spaces to stimulate ongoing thought leadership to address these concerns. The event will explore emerging research and entrepreneurial opportunities in the life sciences sector, and the commercialization constraints entrepreneurs face as they attempt to find viable paths to market, among other pertinent issues. The event will be held on the Rensselaer Polytechnic Institute campus, which has a rich tradition of cutting-edge research and innovation in the life sciences.